We are proud of the world-class educators and researchers we have supported through our grant programs. The following are examples of some of the people and projects we have funded.
Drs. Suzie Pun and Nathan White are developing a medical polymer at the University of Washington with the potential to save hundreds of thousands of lives around the world each year.
Hemorrhagic shock from blood loss is one of the leading causes of death in people under the age of 45, often resulting from trauma incurred in accidents and on the battlefield. Prompt treatment can significantly improve the chance of survival, but current options are limited.
Pun, a professor of bioengineering, and White, an associate professor of emergency medicine, are creating a treatment to prevent hemorrhagic shock. PolySTAT, an easy-to-carry polymer, can be injected to affect internal wounds or applied directly to external wounds to help stanch blood flow. PolySTAT is effective within seconds of application and can mean the difference between a patient dying through exsanguination (“bleeding out”) or surviving long enough to receive appropriate medical treatment.
Following their success with small animal trials, Pun and White are using a $50,000 grant from WRF to scale up production of PolySTAT for testing in large animals. Their goal is for PolySTAT to be saving human lives within a decade.
At Washington State University (WSU), Dr. Kevin Gray and his colleagues in the integrative physiology and neuroscience department are developing a revolutionary cancer treatment.
Chemotherapy drugs cannot target specific cells, so even when successful, treatment also kills healthy cells. This often leads to serious, sometimes fatal, side effects.
Antibody-drug conjugates (ADCs) work by binding chemotherapy drugs to cancer-targeting antibodies produced by the patient. These antibodies then home in on cancer cells, leaving healthy cells alone. However, current ADCs can only utilize a single, relatively low-dose drug, risking poor efficacy and resistance by cancerous cells.
Gray’s team is developing the world’s first multifunctional ADC. Their unique engineering of the proteins involved in the delivery of the drugs allows higher and more diverse doses to be used, increasing the effectiveness of the treatment and expanding the types of cancer that can be treated with ADCs.
WRF provided a $50,000 grant to allow Gray and his colleagues to scale up development and testing of their technique. With help from WSU Innovation Corps, Gray, Dr. Afshin Khan and Alexander Brown formed a company, Chimeric Designs, to enable the treatment to reach the public when it is ready.
Nile Wilson is a fourth-year doctoral student in the University of Washington’s (UW) bioengineering department, co-advised by Dr. Rajesh Rao in computer science and engineering, and Dr. Jeffrey Ojemann in neurosurgery. Wilson’s primary interest is neuroengineering, specifically in systems that allow communication between the human brain and technology for therapeutic and assistive purposes. Such systems have the potential to greatly impact the lives of people with various sensorimotor neural conditions, including epilepsy and spinal cord injuries.
Wilson’s research aims to improve mobility, independence and quality of life for individuals with sensorimotor disabilities through developing more effective Brain-Computer Interfaces, based on improving our understanding of the human brain and building better decoder algorithms as a result.
An ARCS Fellowship funded by WRF helped to bring Wilson to UW for graduate school after she completed her bachelor’s in biomedical engineering at the University of Virginia. A later WRF Innovation Graduate Fellowship has helped her meet the financial demands of gaining her doctorate.
Wilson devotes her remaining time to mentoring other students and engaging with the public through outreach events hosted by UW, The Center for Sensorimotor Neural Engineering and Pacific Science Center.
Bing Brunton is the WRF Innovation Assistant Professor at the University of Washington’s Institute for Neuroengineering (UWIN). She is jointly appointed by UW’s biology department.
Brunton’s research focuses on the intersection of neuroscience and data science—primarily, the ways in which computer models can be used to analyze how large networks of neurons and the electrical signals they use to communicate can give rise to sensation, action, decisions and emotions. Brunton takes vast quantities of data from human and animal brain activity and analyzes it for coherent patterns, looking for correspondences between these patterns and behavior. From this, she builds mathematical models to understand brain function and aims to develop programmatic approaches to intervene during brain dysfunction.
Following her bachelor’s degree in biology from Caltech, Brunton completed her Ph.D. at Princeton. The WRF funding enabled UWIN to hire Brunton, allowing her to make the transition from postdoctoral researcher to faculty and set up a research group in the process.
Brunton was awarded a Sloan Fellowship, which honors “early-career scientists whose achievements and potential identify them as rising stars,” in 2016.
Heart disease is the leading cause of death for men and women in the United States, and Dr. Charles Murry and his team at UW Medicine are committed to changing this within 10 years.
Murry is the co-director of the Institute for Stem Cell and Regenerative Medicine (ISCRM). ISCRM’s Heart Regeneration Program develops stem cell therapies for heart disease, focusing on regenerating heart tissue in patients at risk of congestive heart failure following a heart attack. The tissue damage caused by heart attacks is usually permanent and vastly increases a patient’s risk of future problems.
The Heart Regeneration Program has repaired hearts in animal models by implanting healthy cardiac muscle cells into the damaged heart.
In October 2015, WRF pledged $10 million to Dr. Murry and his colleagues to develop a method of growing healthy cardiac muscle that can be implanted into patients soon after they suffer a heart attack. The hope is to begin testing this novel heart regeneration method in clinical trials by the end of the five-year grant.
Erin dela Cruz is an ARCS Fellow in the University of Washington’s Molecular & Cellular Biology Ph.D. program, which partners UW with local organizations Fred Hutch, Institute for Systems Biology and the Center for Infectious Disease Research.
Dela Cruz’s research focuses on the role of vaginal lactobacilli in the development of bacterial vaginosis BV). BV is a condition that most commonly affects women of reproductive age and can cause premature birth and additional complications if developed during pregnancy. BV also increases the risk of catching or transmitting other STDs, including HIV
Dela Cruz’s findings come from analyzing large data sets derived from patient studies, drawing from the background in applied mathematics and public health she gained at UC Berkeley during her bachelor’s program. The ARCS Fellowship, funded by WRF, was an important factor in her decision to attend UW and has alleviated some of the financial distractions students often face.
Upon completing her Ph.D., dela Cruz plans to pursue her M.D., become a pediatric infectious disease physician and continue research in the field of host-microbe interactions.
Metabolomics concentrates on developing a deep understanding of metabolism by identifying and characterizing many hundreds of small molecules or metabolites within biological systems. It is a relatively new field of study that the University of Washington has targeted as a strategic area of research with significant potential for better fundamental understanding of disease and health, as well as for the translation of new technologies to the clinic.
Dr. Daniel Raftery is an internationally renowned expert in metabolomics, with an emphasis on developing new diagnostics for breast, colon and esophageal cancers, plus new methods of analyzing metabolites in complex biological systems.
A WRF Faculty Recruitment Award of $500,000 has helped bring Dr. Raftery to the UW, where he heads the Northwest Metabolomics Research Center and take up professorships in the Anesthesiology & Pain Medicine and Chemistry Departments. He is also a full member at the Fred Hutchinson Cancer Research Center and previously a professor of chemistry at Purdue University. The grant will provide equipment and staff support for Dr. Raftery’s lab and will assist him in solidifying the program that will help ensure that the UW is at the forefront of world-class metabolomics research.
In the University of Washington's Aeronautics and Astronautics Department, Drs. Uri Shumlak and Brian Nelson are working on the next generation of flow-stabilized light sources for use in extreme ultraviolet lithography (EUV) for the semiconductor industry.
EUV has vast potential in areas including the manufacturing of computer chips. The primary challenges are that current EUV light sources are technologically limited to short bursts and can overload power supplies when run at levels appropriate for high-volume state-of-the-art manufacturing.
Drs. Shumlak and Nelson have developed a new EUV technology that will operate effectively with existing power supplies. A grant of $50,000 from WRF is being used to help them build a functioning prototype of their Flow Z EUV Light Source technology. By enabling the emission of EUV light for significantly longer periods of time, higher output power levels can be achieved and will bridge the gap between the limitations of presently available technology and the requirements to take semiconductor manufacturing to the next level.
Bridget Bertoni is a graduate student in physics working with Professors Ann Nelson and Sanjay Reddy at the University of Washington. The group is studying a model for dark matter in an attempt to understand more about its properties.
A satisfactory description of dark matter has not yet been offered by scientists, despite observations of its effects dating back to the 1930s. Better understanding of these properties will lead to greater insight into the history and detailed particle content of the universe, where it accounts for nearly a quarter of its total energy density.
Ms. Bertoni received her bachelor's degree in physics and mathematics from the University of Pittsburgh. An ARCS Fellowship, funded by Washington Research Foundation, was a strong factor in her decision to pursue a doctorate in theoretical physics at the UW. The opportunity to work with such a distinguished group of scientists, coupled with the financial help offered by ARCS, has greatly energized her work and allowed her to concentrate full time on her studies.